Website of Dr. Joseph George



Citation Index for
siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats
GEORGE J, TSUTSUMI M
GENE THERAPY 14 (10): 790-803 MAY 2007


1.

Huang G, Brigstock DR.
Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2)
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 14 (xx):  2010


[Full PDF]

2.

Brigstock DR
Inhibitors of Connective Tissue Growth Factor (CCN2)-Mediated Fibrogenesis: Underlying Mechanisms and Prospects for Anti-fibrotic Therapy.

In: CCN Proteins in Health and Disease. Perbal A,Takigawa M, Perbal B. (Editors) Springer, New York. pp. 183-204, 2010


[Full PDF]

3.

Muriel P, Arauz J.
Coffee and liver diseases
FITOTERAPIA 81(5) 297-305 JUL 2010

[Full PDF]

4.

Wang JC, Lai S, Guo X, Zhang X, et al.
Attenuation of fibrosis in vitro and in vivo with Sparc siRNA
ARTHRITIS RESEARCH & THERAPY 12: R60 2010

[Full PDF]

5.

Chen F, He S, Qiu R et al.
Influence of silencing TRAF6 with shRNA on LPS/TLR4 signaling in vitro
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY 30 (3): 278-284, MAR 2010


[Full PDF]

6.

George J, Banik NL, Ray SK
Knockdown of hTERT and concurrent treatment with interferon-gamma inhibited proliferation and invasion of human glioblastoma cell lines 
INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY 42 (7): 1164-1173 JUL 2010


[Full PDF]

7.

George J, Banik NL, Ray SK
Genistein induces eeceptor and mitochondrial pathways and increases apoptosis during Bcl-2 knockdown in human malignant neuroblastoma SK-N-DZ Cells
JOURNAL OF NEUROSCIENCE RESEARCH 88 (4): 877-886 MAR 2010

[Full PDF]

8.

George J, Banik NL, Ray SK
Combination of taxol and Bcl-2 siRNA induces apoptosis in human glioblastoma cells and inhibits invasion, angiogenesis and tumour growth
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13 (10): 4205-4218 OCT 2009

[Full PDF]

9.

George J, Banik NL, Ray SK
Combination of hTERT Knockdown and IFN-y Treatment Inhibited Angiogenesis and Tumor Progression in Glioblastoma
CLINICAL CANCER RESEARCH 15 (23): 7186-7195 DEC 2009


[Full PDF]

10.

Chen CH, Zhou YL, Wu YF, et al.
Effectiveness of MicroRNA in Down-Regulation of TGF-ƒÀ Gene Expression in Digital Flexor Tendons of Chickens: In Vitro and In Vivo Study 
JOURNAL OF HAND SURGERY 34 (10): 1777-1784 OCT 2009


[Full PDF]

11.

Dessein A, Chevillard C, Arnaud V, et al.
Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with Schistosomes
JOURNAL OF EXPERIMENTAL MEDICINE 206 (11): 2321-2328 OCT 2009

[Full PDF]

12.

Hu PF, Xie WF
Targeted RNA interference for hepatic fibrosis
EXPERT OPINION ON BIOLOGICAL THERAPY 9 (10):1305-1312 OCT 2009

[Full PDF]

13.

Zhang YJ, Dai Q, Sun DF, et al.
mTOR Signaling Pathway is a Target for the Treatment of Colorectal Cancer
ANNALS OF SURGICAL ONCOLOGY 16 (9): 2617-2628 SEP 2009


[Full PDF]

14.

Weiskirchen R, Meurer SK, Gressner OA, et al.
BMP-7 as antagonist of organ fibrosis
FRONTIERS IN BIOSCIENCE 14: 4992-5012 JUN 2009


[Full PDF]

15.

Tong ZY, Chen RJ, Alt DS, et al.
Susceptibility to Liver Fibrosis in Mice Expressing a Connective Tissue Growth Factor Transgene in Hepatocytes
HEPATOLOGY 50 (3): 939-947 SEP 2009

[Full PDF]

16.

Gressner OA
Less Smad2 Is Good for You! A Scientific Update on Coffee's Liver Benefits
HEPATOLOGY 50 (3): 970-978 SEP 2009

[Full PDF]

17.

Gao RP, Brigstock DR
Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function
WORLD JOURNAL OF GASTROENTEROLOGY 15 (30): 3807-3813 AUG 2009


[Full PDF]

18.

Latella G, Vetuschi A, Sferra R, et al.
Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice
LIVER INTERNATIONAL 29 (7): 997-1009 AUG 2009


[Full PDF]

19.

Gressner OA, Lahme B, Siluschek M, et al.
Connective Tissue Growth Factor Is a Smad2 Regulated Amplifier of Transforming Growth Factor beta Actions in Hepatocytes-But Without Modulating Bone Morphogenetic Protein 7 Signaling
HEPATOLOGY 49 (6): 2021-2030 JUN 2009

[Full PDF]

20.

Gressner OA, Lahme B, Siluschek M, et al.
Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells
LIVER INTERNATIONAL 29 (6): 886-897 JUL 2009

[Full PDF]

21.

Gressner OA
About coffee, cappuccino and connective tissue growth factor-Or how to protect your liver!?
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY  28 (1): 1-10 JUL 2009


[Full PDF]

22.

Gressner OA, Siluschek M, Lahme B, et al.
Intraperitoneal application of caffeine prevents D-galactosamine-induced hepatic expression of connective tissue growth factor (CTGF/CCN2) in the rat
JOURNAL OF HEPATOLOGY  50 (5): 1053-1055 MAY 2009


[Full PDF]

23.

Gressner OA, Gao CF, Rehbein K, et al.
Elevated concentrations of 15-deoxy-Delta(12,14)-prostaglandin J(2) in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs
LIVER INTERNATIONAL 29 (5): 730-735 MAY 2009

[Full PDF]

24.

Chen CC, Lau LF
Functions and mechanisms of action of CCN matricellular proteins
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 41 (4): 771-783 APR 2009

[Full PDF]

25.

Brigstock, D.R.
Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo 
JOURNAL OF CELL COMMUNICATION AND SIGNALING 3 (1): 5-18 JAN 2009


[Full PDF]

26.

Qi, XY, Gao, RP, Zhang, RJ, et al.
Effects of hammerhead ribozyme targeting connective tissue growth factor on collagen I synthesis and cell cycle progression of human hepatic stellate cells 
JOURNAL OF JILIN UNIVERSITY MEDICINE EDITION 35 (1): 26-29 JAN 2009


[Full PDF]

27.

Nan YM, Fu N, Wu WJ, et al.
Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 44 (3): 358-365 2009

[Full PDF]

28.

George J, Banik NL, Ray SK
Bcl-2 siRNA Augments Taxol Mediated Apoptotic Death in Human Glioblastoma U138MG and U251MG Cells
NEUROCHEMICAL RESEARCH 34 (1): 66-78 JAN 2009

[Full PDF]

29.

Gao L, Zhang Y, Qiu W, et al.
Effects of PI3-k/Akt short hairpin RNA on proliferation, fibronectin production and synthesis of thrombospondin-1 and transforming growth factor-ƒÀ1 in glomerular mesangial cells induced by sublytic C5b-9 complexes
CELL PROLIFERATION 42 (1): 83- 93 JAN 2009


[Full PDF]

30.

Chen CH, Cao Y, Wu YF, et al.
Tendon Healing In Vivo: Gene Expression and Production of Multiple Growth Factors in Early Tendon Healing Period
JOURNAL OF HAND SURGERY-AMERICAN VOLUME 33A (10): 1834-1842 DEC 2008


[Full PDF]

31.

Hu PF, Zhu YW, Zhong W, et al.
Inhibition of plasminogen activator inhibitor-1 expression by siRNA in rat hepatic stellate cells
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 23  (12): 1917-1925    DEC 2008

[Full PDF]

32.

Gressner OA
Antifibrotic effects of caffeine on chronic liver diseases - Epidemiologic observations and pathophysiological background
MEDIZINISCHE WELT 59 (12): 491-497 DEC 2008


[Full PDF]

33. Gressner OA, Lahme B, Rehbein K, et al.
Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPAR gamma and SMAD2/3-dependent pathways
JOURNAL OF HEPATOLOGY 49 (5): 758-767 NOV 2008

[Full PDF]

34.

Perugorria MJ, Latasa MU, Nicou A, et al.
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis
HEPATOLOGY 48 (4): 1251-1261 OCT 2008


[Full PDF]

35.

Gressner OA, Lahme B, Siluschek M, et al.
Intracrine signalling of activin A in hepatocytes upregulates connective tissue growth factor (CTGF/CCN2) expression
LIVER INTERNATIONAL 28 (9): 1207-1216 OCT 2008


[Full PDF]

36.

Zhang B, Wang LT
Bushen Rougan Recipe in prevention of hepatic fibrosis in rats induced by dimethylnitrosamine: A study on its preliminary mechanism 
JOURNAL OF CHINESE INTEGRATIVE MEDICINE 6 (9): 934-938 SEP 2008

[Full PDF]

37.

Gressner OA, Gressner AM
Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases
LIVER INTERNATIONAL 28 (8) 1065-1079 SEP 2008

[Full PDF]

38.

Gressner OA, Rizk MS, Kovalenko E, et al.
Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go?
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 23 (7): 1024-1035 JUL 2008


[Full PDF]

39.

Qi XY, Gao RP, Wang SH et al.
Inhibitory effect of hammerhead ribozyme targeting connective tissue growth factor on TGF-ƒÀ1-induced collagen I synthesis in human hepatic stellate cells 
WORLD CHINESE JOURNAL OF DIGESTOLOGY 16 (23): 2587-2591 DEC 2008


[Full PDF]

40.

Ban CR, Twigg SM
Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers
VASCULAR HEALTH AND RISK MANAGEMENT 4 (3): 575-596 JUN 2008

[Full PDF]

41.

Zhang B, Wang LT
Effects of kidney-tonifying liver-emoliating formula on connective tissue growth factor mRNA expression in hepatic fibrosis rats 
WORLD CHINESE JOURNAL OF DIGESTOLOGY 16 (20): 2224-2228 OCT 2008

[Full PDF]

42.

George J.
Elevated serum beta-glucuronidase reflects hepatic lysosomal fragility following toxic liver injury in rats.
BIOCHEMISTRY AND CELL BIOLOGY 86 (3): 235-243, JUN 2008


[Full PDF]

43.

Zhu YH, Ren WH, Sun CG, et al.
Disruption of connective tissue growth factor by short hairpin RNA inhibits collagen synthesis and extracellular matrix secretion in hepatic stellate cells?
LIVER INTERNATIONAL 28  (5): 632-639 MAY 2008


[Full PDF]

44.

Liu N, Zhang XL
Gene therapy for hepatic fibrosis
SHIJIE HUAREN XIAOHUA ZAZHI 16 (3): 284-288 JAN 2008

[Full PDF]

45.

Gressner OA, Weiskirchen R, Gressner AM.
Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options.
COMPARATIVE HEPATOLOGY 6: 7 (p.1-13) JUL 2007

[Full PDF]


home

Documents placed here are for information purposes only. Downloading, saving, printing or electronic duplication of these documents are prohibited under copyright law.